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What we offer:
We provide our probes for research testing upon request, subject to availability. Researchers interested in any of our probes are encouraged to reach out to us directly at xiongr@arizona.edu. Additionally, most probes listed below are available through commercial vendors for research purposes.
TTC-352
Estrogen Receptor Partial Agonist
Phase I/II clinical trials
Clinical trial ID: NCT03201913
J. Med. Chem. 2016, 59, 219–237
X-ray co-crystal structure PDB: 7JHD
Commercial availability: yes (click)
Rintodestrant
Estrogen Receptor Degrader
Clinical trial ID: NCT03455270
J. Med. Chem. 2017, 60, 1325–1342
Commercial availability: yes (click)
XP-524 (YF2-23)
Dual BET/P300 inhibitor
Preclinical development
PNAS, 2022, 119(4):e2116764119
X-ray co-crystal structure PDB: 6P05 & 7JUO
Commercial availability: yes (click)
XR8-23
SARS-CoV-2 PLpro inhibitor
Preclinical development
J. Med. Chem. 2022, 65, 2940–2955
X-ray co-crystal structure PDB: 7LBS (a close analog)
Commercial availability: No
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