Development and optimization of protease inhibitors.

• https://pubs-acs-org.ezproxy2.library.arizona.edu/doi/10.1021/acs.jmedchem.1c01307

Identification of small molecules that can sensitize cold tumors to immune checkpoint inhibitors. The pathway we are interested in involves inducing mismatch repair deficiency to activate neo-antigen presentation.

Developing new chemical-biology probes to accelerate drug discovery.

Developing new covalent electrophilic scaffolds to address some undruggable oncogenic targets, such as the KRAS G12D mutation.

Mixing cheminformatics and rational design to develop algorithms that aid the medcinal chemist.